Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Investigation of In vitro Release Kinetics of Carbamazepine from Eudragit - RS PO and RL PO Matrix Tablets

Apurba Sarker Apu¹ , Atiqul Haque Pathan¹, Dilasha Shrestha², Golam Kibria², Reza-ul Jalil²

¹Department of Pharmacy, East West University, Mohakhali, Dhaka-1212; ²Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.

For correspondence:- Apurba Apu Email: apurba2sarker@yahoo.com Tel:0088029882308

Received: 30 July 2008 Accepted: 28 December 2008 Published: 17 April 2009

Citation: Apu AS, Pathan AH, Shrestha D, Kibria G, Jalil R. Investigation of In vitro Release Kinetics of Carbamazepine from Eudragit - RS PO and RL PO Matrix Tablets. Trop J Pharm Res 2009; 8(2):145-152 doi: 10.4314/tjpr.v8i2.8

© 2009 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: The objective of this research work was to prepare and evaluate the effect of Eudragit RS PO and Eudragit RL PO polymers on the physical property and release characteristics of carbamazepine matrix tablets.

Methods: Matrix tablets containing carbamazepine were prepared with Eudragit^® RS PO alone as the rate-retarding polymer (coded batch series ‘A’) and also with a combination of Eudragit^® RS PO and RL PO (coded batch series ‘B’). The tablets were characterized for hardness as well as for carbamazepine release. The release data were subjected to different models in order to evaluate their release kinetics and mechanisms.

Results: The hardness of batch series ‘A’ matrix tablet was >160 kg/cm² while for batch series ‘B’, it was >170 kg/cm². Carbamazepine tablets containing only Eudragit RS PO showed very slow release (less than 6% in 8 h) but when Eudragit RL PO was blended with Eudragit RS PO, the release rate improved significantly to 44% in 24 h (p < 0.05). Drug release mechanism was a complex mixture of diffusion and erosion.

Conclusion: Carbamazepine matrix tablets of satisfactory hardness were produced. Furthermore, by blending Eudragit RS PO with Eudragit RL PO in the matrix, tablets of varying release characteristics can be prepared.

Keywords: Carbamazepine, Matrix tablet, Hardness, EudragitÂ® RS PO, EudragitÂ® RL PO, Release kinetics